Integration of genomic analysis and transcript expression of ABCC8 and KCNJ11 in focal form of congenital hyperinsulinism

BackgroundThe focal form of CHI is caused by an autosomal recessive pathogenic variant affecting the paternal homologue of genes ABCC8 or KCNJ11 and a second somatic event specifically occurring in the affected islet of Langerhans.The approach of this study was to integrate the genetic changes occurring in pancreatic focal lesions of CHI at the gen

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Screening of antibiofilm and anti-quorum sensing activty of Actinomycetes isolates extracts against aquaculture pathogenic bacteria

Abstract Background Indonesia is the third largest producer of fish and other aquaculture products in the world, making this industry a major contributor in the economy of Indonesia.However, this industry continually overcome challenges, one of them are bacterial outbreaks.In addition, the emergence of these bacterial outbreaks were worsen due to t

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